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. 2019 Sep 17;9:13471. doi: 10.1038/s41598-019-50029-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heterogeneity of peripheral T-cell profiles in FL patients before treatment. (a) Hierarchical clustering of FL patients (n = 33) based on peripheral T-cell phenotypes before treatment. Phenotypes of analyzed T-cell subsets are indicated on the right. N indicates naive, CM central memory, EM effector memory, and EMRA effector memory RA⁺, CD4⁺ or CD8⁺ T cells. Patient numbers are indicated below the diagram. The heatmap is colored according to row Z-scores. Some of the values are missing in three patients (grey squares). Patient response to treatment is indicated below column dendrogram. Green = complete responders (CR); pink = partial responders (PR) and progressors. (b,c) Scatter plots of flow cytometry data obtained from pre-treatment blood samples of CR patients (n = 25) or PR/progressors patients (n = 7) or healthy donors (HD, n = 23). (b) Percentages of CCR7⁺CD45RA⁺ naive (T_N) cells among CD4⁺ T cells and ratios of CD4⁺ T_N/T_EM or T_N/T_CM subsets. (c) Percentages of CCR7⁺CD45RA⁺ naive (T_N) among CD8⁺ T cells and ratios of CD8⁺ T_N/T_EM or T_N/T_CM subsets. A Mann-Whitney test was performed for statistical analyses. *p < 0.05; **p < 0.01; ***p < 0.001; ****p < 0.0001; ns: not significant.