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. 2019 Sep 17;9:13458. doi: 10.1038/s41598-019-49682-0

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Notch Inhibition minimizes collagen and ECM degradation. (A) Representative trichrome images of aorta showing collagen contents in the indicated groups. (B) Representative transmission electron microscopy (TEM) images comparing collagen bundles/fibers and D-spacing of collagen molecules. (C) Quantification of D-spacing in experimental groups as determined by TEM (n = 4). Tukey multiple comparisons test was used for data analysis in C. *P < 0.05; **P < 0.01; ***P < 0.001. Scale bar = 50 µm in A and 5 µm in top, 0.2 µm in the middle and 50 nm in the lower panel of B.