Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 17;9:13439. doi: 10.1038/s41598-019-49513-2

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

(a) Displacement of the magnetic TiO₂NTs internalized in a single HeLa cell by employing magnetic force, -I- a representative light microscopic image of a treated cell and -II- measured displacement of representative magnetic TiO₂NTs (indicated by blue, orange, and green cycles). Red dashed lines (at 5 and 10 sec) show the period that the magnetic tweezer device was active. (b) Cumulative camptothecin release profiles from camptothecin-loaded magnetic TiO₂NTs (black squares) and camptothecin-loaded TiO₂NTs (red squares). Release medium: PBS, pH 7.4, T = 37 °C. (c) Effects of anticancer camptothecin delivery, using magnetic TiO₂NTs under the influence of a gradient magnetic field. HeLa cells incubated for 30 min with nanocarriers under the influence of a static gradient magnetic field were thoroughly washed in order to eliminate the unbound nanocarriers and then incubated with fresh cell culture medium (without nanocarriers) for 72 h. Cell viability of HeLa cells treated with camptothecin-loaded magnetic TiO₂NTs (Δ) and empty magnetic TiO₂NTs (□) under the influence of a gradient magnetic field, as well as camptothecin-loaded magnetic TiO₂NTs (◯) and empty magnetic TiO₂NTs (◊) without employing the gradient magnetic field were measured after 72 h of incubation (T = 37 °C, 5% CO₂).