Table 1.
The top recurring single point driver mutations in coding regions proposed by Rheinbay et al. (Extended Data Fig. 1 in27).
| Gene | Chr. | Position | Ref. | Mut. | Confidences |
|---|---|---|---|---|---|
| KRAS | 12 | 25398284 | C | {A, G, T} | {0.922, 0.916, 0.910} |
| KRAS | 12 | 25398285 | C | {A, G, T} | {0.931, 0.915, 0.902} |
| PIK3CA | 3 | 178952085 | A | {C, G, T} | {0.854, 0.804, 0.829} |
| PIK3CA | 3 | 178936091 | G | {A, C, T} | {0.959, 0.949, 0.991} |
| TP53 | 17 | 7577120 | C | {A, G, T} | {0.887, 0.920, 0.876} |
| TP53 | 17 | 7577538 | C | {A, G, T} | {0.932, 0.951, 0.909} |
| TP53 | 17 | 7577094 | G | {A, C, T} | {0.819, 0.853, 0.322} |
| TP53 | 17 | 7578212 | G | {A, C, T} | {0.989, 0.854, 0.443} |
| TP53 | 17 | 7578190 | T | {A, C, G} | {0.926, 0.916, 0.915} |
| TP53 | 17 | 7577539 | G | {A, C, T} | {0.877, 0.907, 0.459} |
| TP53 | 17 | 7577121 | G | {A, C, T} | {0.760, 0.875, 0.717} |
| NRAS | 1 | 115256530 | G | {A, C, T} | {0.987, 0.911, 0.931} |
| IDH1 | 2 | 209113112 | C | {A, G, T} | {0.940, 0.957, 0.926} |
Their study uses data from the Pan-Cancer Analysis of Whole Genomes Consortium and uses in excess of 2,700 cancer genomes from more than 2,500 patients. This table only gives single nucleotide variants located on autosomes and labelled by our classifier as residing in coding regions (the corresponding table for non-coding mutations is presented in Supplementary Section 6). The table presents the gene, chromosome (Chr.), position and reference nucleotide (Ref.) based on the GRCh37 reference genome. The three prospective variants are presented (Mut.) with the confidence driver-status given in the next column, in the same relative order, and derived from our predictor CScape (http://cscape.biocompute.org.uk).