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. 2019 Sep 17;9:13432. doi: 10.1038/s41598-019-48602-6

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Scanned images of a representative area of LCIS from a single case. The H&E-stained image (panel a) was used as a guide to mark the areas of epithelial tissue for analysis (annotations shown in yellow). Markers were stained using dual-immunofluorescence. MMP2 (panel b) and MMP9 (panel c) were visualized with Cy5 (red), whereas MMP14 (panel d) and collagen IV (panel e) were visualized with Cy3 (green). The images are shown at 20x magnification.