Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Sep 17;10:4223. doi: 10.1038/s41467-019-11982-4

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Loss of JNK3 (Mapk10) promotes blood flow recovery after hindlimb ischemia (HLI). JNK3 protein expression from human peripheral nerves and muscle (a) as well as mRNA expression from mouse gastrocnemius muscle (b) were measured by western blot or qRT-PCR after tissues were harvested from either control or ischemic areas of peripheral limbs (n = 4 in each group). c Time course of blood flow recovery by laser Doppler imaging in HLI of mice with the indicated genotype (WT, n = 4; Mapk10^+/−, n = 5; Mapk10^−/−, n = 4). d Representative figures of blood flow measurements by laser Doppler iImaging in hindlimb ischemia model at day 7 post HLI of control and Mapk10^−/− mice. e Expression of von Willebrand factor (vWF) in mouse thigh adductor muscle on day 21 after femoral artery ligation. f Quantification of diameter of collateral vessels, vWF, in mouse thigh adductor muscle on day 21 after femoral artery ligation (WT control, n = 32; Mapk10^−/− control, n = 24; WT ischemia, n = 31; Mapk10^−/− ischemia, n = 32). g Cluster of differentiation 31 (CD31) also known as platelet endothelial cell adhesion molecule (PECAM-1) expression in mouse gastrocnemius muscle on day 21 after femoral artery ligation. h CD31 quantification, in mouse gastrocnemius muscle on day 21 after femoral artery ligation (n = 4 in each group). *P < 0.05 vs. indicated comparison by Student’s t test. The data are mean ± SEM. Scale bar, 60 μm. Source data are provided as a Source Data file