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. 2019 Sep 11;7:190. doi: 10.3389/fcell.2019.00190

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Copyright © 2019 Luo and Boyce.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of COPI trafficking by ubiquitination. (A) In yeast, ubiquitination of the SNARE Snc1 allows for coatomer binding through β′- and α-COP, leading to recycling to the plasma membrane. (B) Androgen receptor signaling by dihydrotestosterone has been found to activate the ubiquitin ligase PIRH2, which targets ε-COP for proteasomal degradation. Single arrows indicate functional interaction. Double-headed arrows indicate translocation. AR, androgen receptor; DHT, dihydrotestosterone; PIRH2, p53-induced RING-H2 protein; PM, plasma membrane; Snc1, synaptobrevin homolog 1; Ub, ubiquitination.