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. 2019 Sep 11;10:2089. doi: 10.3389/fmicb.2019.02089

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Copyright © 2019 Rothan, Arora, Natekar, Strate, Brinton and Kumar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of survival and clinical score in WT and ZBP1^−/− mice following WNV infection. WT and ZBP1^−/− mice were inoculated subcutaneously via footpad with (A) WNV NY99 (100 PFU) or (B) WNV Eg101 (1,000 PFU). The difference in the survival of WT and ZBP^−/− mice was statistically significant for both WNV NY99 and WNV Eg101 (n = 12–22 mice per group). (C,D) Animals were monitored twice daily for clinical signs. The designation for the clinical scores is as follows: 1, ruffled fur/hunched back; 2, paresis/difficulty walking; 3, paralysis; 4, moribund/euthanized; and 5, dead. Error bars represent SEM, ^*p < 0.05, ^**p < 0.001.