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Analysis of virus titers produced by primary cells isolated from WT and ZBP1−/− mice. (A–D) MEFs and neuronal cultures were infected with WNV NY99 or WNV Eg101 (as described in Materials and Methods) and virus titers in the cell culture supernatants were measured by plaque assay. Results are expressed as PFU/ml ± SEM from at least three independent experiments conducted in duplicate. *p < 0.05, **p < 0.001.
