Table 1.
Significant differential abundance proteins in microvascular smooth muscles contracted by high potassium with or without Neo treatment.
| No. | Accession | Description | Gene name | Coverage% | Unique peptides | Model/Controla | Drug/Modela | Drug/Controla | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Ratio | Trendb | Ratio | Trendb | Ratio | Trendb | ||||||
| 1 | B2RTM0|B2RTM0 | Histone H4 | Hist2h4 | 75.73 | 26 | 4.0878 | + | 0.6009 | − | 1.1934 | = |
| 2 | Q8C7E4|Q8C7E4 | Ribonuclease 4 | Rnase4 | 47.97 | 5 | 1.8118 | + | 0.4053 | − | 0.8918 | = |
| 3 | Q3TML0|Q3TML0 | Protein disulfide-isomerase A6 | Pdia6 | 39.33 | 21 | 1.7278 | + | 0.5197 | − | 0.8679 | = |
| 4 | Q542P5|Q542P5 | Carbonyl reductase 2, isoform CRA_b | Cbr2 | 56.15 | 16 | 1.8813 | + | 0.4372 | − | 0.8644 | = |
| 5 | Q545V2|Q545V2 | Protein S100 | S100a4 | 41.58 | 4 | 3.2510 | + | 0.1462 | − | 0.8438 | = |
| 6 | F8VQN6|F8VQN6 | Rho guanine nucleotide exchange factor 12 | Arhgef12 | 19.56 | 6 | 1.7119 | + | 0.4244 | − | 0.8390 | = |
| 7 | Q571M2|Q571M2 | MKIAA4025 protein (Fragment) | Hspa4 | 63.23 | 45 | 2.2777 | + | 0.5193 | − | 0.8136 | = |
| 8 | F6XC54|F6XC54 | Protein diaphanous homolog 1 | Diaph1 | 24.10 | 14 | 1.8690 | + | 0.4649 | − | 0.7608 | = |
| 9 | Q542X9|Q542X9 | Superoxide dismutase [Cu–Zn] | Sod3 | 70.52 | 27 | 1.9040 | + | 0.3802 | − | 0.7293 | = |
| 10 | Q3UKV0|Q3UKV0 | Protein Eif2b3 | Eif2b3 | 23.60 | 3 | 1.5633 | + | 0.4900 | − | 0.7169 | = |
| 11 | Q3T9Z2|Q3T9Z2 | Glyoxylate reductase/hydroxy pyruvate reductase | Grhpr | 49.09 | 12 | 2.3454 | + | 0.5056 | − | 0.6958 | − |
| 12 | Q921W7|Q921W7 | Putative uncharacterized protein Tes | Tes | 36.75 | 8 | 3.5798 | + | 0.4937 | − | 0.6931 | − |
| 13 | E3VRY6|E3VRY6 | Large conductance Ca2+-activated potassium channel ERL variant 4 | Kcnma1 | 12.04 | 1 | 44.913 | + | 0.3659 | − | 0.6795 | − |
| 14 | Q91UZ1|Q91UZ1 | Phosphoinositide phospholipase C | Plcb4 | 40.34 | 21 | 2.0192 | + | 0.3706 | − | 0.4815 | − |
| 15 | Q6NXL1|Q6NXL1 | Protein Sec24d | Sec24d | 26.45 | 11 | 3.5485 | + | 0.5153 | − | 0.4740 | − |
| 16 | Q58EU7|Q58EU7 | Rbp1 protein | Rbp1 | 78.52 | 18 | 3.5583 | + | 0.5040 | − | 0.3738 | − |
a
Model/control: the average ratios for model→control; drug/model: the average ratios for drug→model; drug/control: the average ratios for drug→control.
b
+: by adoption of ratio >1.5-fold for upregulated cutoff values; −: by adoption of ratio <0.7-fold for downregulated cutoff values; =: by adoption of ratio <1.5-fold and >0.7-fold, not significantly changed.