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. 2019 Sep 17;9:13495. doi: 10.1038/s41598-019-49756-z

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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cMet agonistic Ab and kidney fibrosis in a unilateral ureteral obstruction (UUO) mouse model. (A) Representative images of kidney sections stained with Masson’s trichrome stain in IgG control- or cMet Ab-treated mice at day 14 after UUO. Original magnification: X20. Scale bar, 200 µm. Symbols represent individual data points, horizontal bars indicate the mean, and error bars indicate SEM. (B) cMet expression in proximal tubular cells in n IgG control- or cMet Ab-treated mice at day 14 after UUO. DAPI (blue), cMet (green), and aquaporin-1 (red).Original magnification: X400. Scale bar, 50 µm. (C,D) The expression levels of fibronectin and collagen 1 were increased and those of E-cadherin were decreased in the cMet group, and treatment with the cMet agonistic Ab prevented fibrosis as indicated by western blot. (E) Quantitative RT-PCR analyses of the indicated mRNA transcript showed similar expression patterns as those observed by western blot. The combined data represent at least 2 independent experiments with similar results. Symbols represent individual data points, horizontal bars indicate the mean, and error bars indicate SEM (*p < 0.05, **p < 0.01, ***p < 0.001).