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. 2019 Sep 11;10:1002. doi: 10.3389/fphar.2019.01002

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Copyright © 2019 Qiu, Wang, Liu, Wang, Zhao, Zhou, Ji, Wang, Xia, Wang, Lin, Liu, Huang and Jiang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Apigenin inhibited the growth of esophagus cancer in nude mice xenografted with Eca-109 cells. Nude mice were injected subcutaneously with Eca-109 cells, randomly divided into five groups, and treated by intraperitoneal injection with the following regimens: vehicle alone (0.9% saline) and apigenin (1, 3, 5, and 10 mg/kg) every other day. (A) The tumor volume, (B) photos of the tumors, (C), tumor weight, and (D) body weight. The collected tumor tissues were analyzed by quantitative PCR and immunohistochemical analysis. (E) The immunohistochemical Ki67 and CD31 staining, (F) quantified positive cells, and (G) IL-6 expression level as detected by ELISA. The values presented are the means ± SD. *P < 0.05 and ** P < 0.01 indicate significant difference from the corresponding control (n = 6).