Table 5.
Univariate and multivariate Cox regression analyses of OS in 76 enrolled ACC patients.
| Univariate analysis | Multivariate analysis* | |||
|---|---|---|---|---|
| Covariates | HR (95%CI) | P value | HR (95%CI) | P value |
| Age at diagnosis (≤57 years vs. >58 years) | 1.957 (0.913 – 4.196) | 0.085 | 4.959 (1.744 – 14.098) | 0.003 |
| Gender (male vs. female) | 0.996 (0.466 – 2.127) | 0.991 | ||
| Laterality (left vs. right) | 1.262 (0.591 – 2.695) | 0.548 | ||
| T stage (T1-T2 vs. T3-T4) | 10.693 (4.276 – 28.110) | <0.001 | ||
| N stage (N0 vs. N1) | 0.451 (0.171 – 1.191) | 0.108 | ||
| M stage (M0 vs. M1) | 7.340 (3.300 – 16.327) | <0.001 | 3.045 (1.094 – 8.477) | 0.033 |
| Pathologic stage (I - II vs. III - IV) | 7.157 (3.023 – 16.941) | <0.001 | ||
| Mitotic rate (≤5/50 HPF vs. >5/50 HPF) | 1.708 (0.743 – 3.926) | 0.208 | ||
| Invasion of tumor capsule (Present vs. Absent) | 3.015 (1.257 – 7.231) | 0.013 | ||
| Sinusoid invasion (Present vs. Absent) | 3.069 (1.297 – 7.262) | 0.011 | ||
| Necrosis (Present vs. Absent) | 5.135 (1.214 – 21.725) | 0.026 | ||
| Weiss score (≤3 vs. >3) | 3.467 (1.136 – 10.577) | 0.307 | ||
| New tumor event (Present vs. Absent) | 5.833 (2.351 – 14.473) | <0.001 | 3.609 (1.305 – 9.980) | 0.013 |
| Integrated expression score (High vs. Low) | 18.892 (6.830 – 52.255) | <0.001 | 18.719 (5.122 – 68.415) | <0.001 |
OS, overall survival; ACC, adrenocortical carcinoma; HR, hazard ratio; CI, confidence interval; HPF, high power field.
*Multivariate cox regression analyses of DFS in 76 enrolled ACC patients was run in “Back-LR” method. Statistically significant is considered as P value less than 0.05, indicated in bold.