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. 2019 Sep 11;10:2134. doi: 10.3389/fimmu.2019.02134

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Copyright © 2019 Ellyard, Tunningley, Lorenzo, Jiang, Cook, Chand, Talaulikar, Hatch, Wilson, Vinuesa, Cook and Fulcher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heat mapping with continuous color shading (as depicted in Figure 2A) in PAD patients. Heat maps from individual patients (labeled a to v) are ordered from left to right based on increasing proportions of switched memory B cells (B-SM), with the cut-off of 0.4% of total lymphocytes shown. The expansion of CD21-lo B cells can be readily appreciated (labeled), as can the expansion in CXCR5+/CD45RA–CD4 T cells (X5-Th), and Tfh-effector cells and (as a percentage of CD4 T cells). Inset shows the comparisons between control values (n = 77) and PAD patients for X5-Th and Tfh-effector cells. Details of PAD patients presented in Supplementary Table 2.