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. 2019 Sep 11;10:2134. doi: 10.3389/fimmu.2019.02134

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Copyright © 2019 Ellyard, Tunningley, Lorenzo, Jiang, Cook, Chand, Talaulikar, Hatch, Wilson, Vinuesa, Cook and Fulcher.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of cellular parameters in a CTLA4 haploinsufficient kindred. (A) Heat mapping with discontinuous shading showing changes in cell populations for the CTLA4 haploinsufficient proband with CVID, in comparison with the clinically normal brother with the CTLA4 mutation, the unaffected proband's adult daughter without CTLA4 mutation and the internal control. Boxes highlight parameters for which cellular changes differ between the two CTLA4 mutants, the unaffected subjects, and between the CTLA4 mutants with or without clinical expression. (B) Scatter plots showing raw values for populations identified in (A), along with representative FCM contour plots of these critical parameters (C). Raw and centile data is presented in Supplementary Table 3.