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Inhibition of tubulin polymerization and [3H] colchicine binding inhibition.
| Hits | ID Number | Tubulin IC50 [μM] a | [3H] Colchicine Binding Inhibition (% ± SD) b |
|---|---|---|---|
| 1 | AG-690/11549747 | 3.7 ± 0.5 | 91 ± 5.5 |
| CA-4 | 3.3 ± 0.6 | 96 ± 3.1 |
a Inhibition of tubulin polymerization. The tubulin concentration was 10 µM. b Inhibition of colchicine binding. The compound concentration was 20 µM. The results are representative of three independent experiments and are expressed as mean ± SD.
