Table 2.
Inhibition of chemokine and cytokine production by compounds 1–6.
| Chemokine and Cytokine | 1 | 2 | 3 | 4 | 5 | 6 |
|---|---|---|---|---|---|---|
| IC50 (μM) | ||||||
| MCP-1 | 8.5 ± 2.3 a | 78.7 ± 1.1 d | 74.2 ± 5.5 b | 13.7 ± 4.1 ab | <100 | 15.2 ± 1.1 ab |
| TARC | 6.9 ± 0.4 a | 42.6 ± 1.9 c | 20.7 ± 2.2 b | 11.2 ± 1.5 ab | 42.5 ± 2.5 c | 16.2 ± 1.5 ab |
| IL-6 | 16.4 ± 2.1 ab | 39.0 ± 2.2 bc | 36.3 ± 3.1 b | 14.5 ± 1.7 a | 37.8 ± 2.6 bc | 16.6 ± 0.8 a |
| IL-8 | 16.5 ± 1.3 b | 26.4 ± 0.9 c | 40.1 ± 1.5 d | 18.5 ± 0.3 b | 3.1 ± 1.2 a | 25.8 ± 0.7 c |
| IL-10 | 5.4 ± 0.6 a | 8.9 ± 1.1 a | 15.7 ± 4.3 bc | 7.3 ± 0.6 a | 13.6 ± 1.5 b | 15.6 ± 2.3 b |
| IL-13 | 16.1 ± 1.4 a | 40.4 ± 2.6 c | 44.8 ± 2.2 c | 26.2 ± 0.5 b | 32.6 ± 0.5 bc | 28.1 ± 0.9 b |
Values represent the means ± S.D. of three determinations. Values with different superscripts in the same columns are significantly different (p < 0.05).