Table 3.

Antiproliferative activity of the isolated sesquiterpenoids, flavonoids, and coumarin.

		Inhibition of Cell Proliferation (%) ± SEM [Calculated IC50 (μM)]
Compound	Conc.	SiHa	HeLa	MDA-MB-231
Chlorojanerin (1)	10 μM	82.10 ± 0.97	51.83 ± 2.43	90.55 ± 1.27
	30 μM	92.93 ± 0.35	77.08 ± 0.80	92.00 ± 0.68
		[6.71]	[11.37]	[2.21]
19-Deoxychlorojanerin (2)	10 μM	90.93 ± 1.32	96.17 ± 0.38	96.14 ± 0.51
	30 μM	95.80 ± 0.15	96.14 ± 0.48	97.42 ± 0.36
		[5.54]	[4.86]	[2.88]
15-Hydroxyjanerin (3)	10 μM	<10	<10	<10
	30 μM	<10	<10	<10
Aguerin B (4)	10 μM	89.09 ± 1.54	28.87 ± 0.83	96.23 ± 0.45
	30 μM	97.92 ± 0.41	97.50 ± 0.31	96.64 ± 0.71
		[5.70]	[12.64]	[4.26]
Cynaropicrin (5)	10 μM	63.03 ± 1.25	34.36 ± 2.37	92.16 ± 0.68
	30 μM	90.75 ± 0.55	68.26 ± 1.85	93.45 ± 0.27
		[8.39]	[12.99]	[4.80]
Eleganin (6)	10 μM	64.97 ± 2.06	16.54 ± 1.48	89.44 ± 1.36
	30 μM	90.89 ± 0.43	73.99 ± 1.68	92.09 ± 0.9
		[7.57]	[19.62]	[6.86]
Apigenin	10 μM	<10*	18.81 ± 0.80	<10
	30 μM	29.92 ± 1.75	70.43 ± 1.09	28.42 ± 1.04
Jaceosidine	10 μM	18.88 ± 2.99	<10	<10
	30 μM	60.08 ± 0.74	75.18 ± 0.68	40.04 ± 1.68
6-Methoxyluteolin	10 μM	14.16 ± 1.49	88.00 ± 0.63	<10
	30 μM	35.20 ± 2.08	93.74 ± 0.65	26.55 ± 2.12
			[4.50]
Scopoletin	10 μM	<10	<10	12.09 ± 2.59
	30 μM	17.18 ± 2.18	<10	15.85 ± 1.85
Cisplatin	10 μM	88.64 ± 0.50	42.61 ± 2.33	67.51 ± 1.01
	30 μM	90.18 ± 1.78	99.93 ± 0.26	87.75 ± 1.10
		[7.84]	[12.43]	[3.74]

* Antiproliferative activities less than 10% are considered negligible and not given numerically.