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The mechanisms of neuroprotective activity exhibited by auraptene. COX-2, cyclooxygenase-2; iNOS, inducible nitric oxide synthase; TNF-α, tumor necrosis factor-alpha; GSH, glutathione; SOD, superoxide dismutase; MDA, malondialdehyde; PGE2, prostaglandin E2; CREB, cAMP response element-binding protein; ERK1/2, extracellular signal-regulated kinase 1 or 2.
