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Mechanism of amyloid formation. aRate‐limiting step involves dissociation of tetrameric TTR to a pair of dimeric TTRs, which rapidly progresses to monomeric TTR. bMisfolded protein can form a variety of toxic intermediates, including amyloid fibrils (shown here); small oligomers; and amorphous aggregates. TTR, transthyretin. Modified with permission from Bulawa et al. (2012)
