Table 1.

Signs, symptoms, and “red‐flag” manifestationsa of ATTR amyloidosis (Castano et al., 2016; Coelho et al., 2008; Conceicao et al., 2016; Donnelly & Hanna, 2017; Galat et al., 2016; Geller et al., 2017; Gertz, 2017; Ruberg & Berk, 2012; Sperry et al., 2018)

	Signs, symptoms, and manifestationsb
Neuropathy	Progressive symmetric peripheral sensorimotor neuropathy (plus ≥ 1 other “red‐flag” manifestation) is suggestive of hATTRa
Bilateral carpal tunnel syndrome	Bilateral carpal tunnel syndrome (especially if family history)a
Autonomic neuropathy	Orthostatic hypotensiona Erectile dysfunctiona Recurrent urinary tract infection (due to urinary retention) Sexual dysfunction Sweating abnormalities
Cardiovascular manifestations	Irregular heartbeat (atrial fibrillation most common)a Conduction blocks (including bundle branch blocks)a Congestive heart failure (including shortness of breath, generalized fatigue, and peripheral edema) Ventricular wall thickening with preserved ejection fraction and absence of left ventricular dilationa Cardiomyopathy Mild regurgitation
Gastrointestinal manifestations	Nausea and vomiting Early satiety Chronic diarrheaa Severe constipationa Diarrhea/constipationa Unintentional weight lossa
Nephropathy	Albuminuriaa Mild azotemiaa Protein in urine Renal failure
Ocular manifestations	Dark floatersa Glaucoma Abnormal blood vessels in eye Pupillary abnormalities
Other	Lumbar spinal stenosisa Spontaneous distal biceps tendon rupturea

Abbreviations: ATTR, amyloid transthyretin; hATTR, hereditary amyloid transthyretin amyloidosis.

^aRed‐flag manifestations.

^bCentral nervous system symptoms can occur with certain TTR mutations but are not a common manifestation.