Table. Predicted MOE for Top-Marketed Pulegone-Containing Smokeless Tobacco and e-Cigarette Liquids Used in Vape Tanks and Vape Mod Devices.
| Type and Flavora | Pulegone Concentration (μg/g) | MOE for Daily e-Liquid (mL/d) or Smokeless Tobacco (g/d) Amount Consumedb | Fold Increase in Daily Exposure Compared With Menthol Cigarette Usec | |||
|---|---|---|---|---|---|---|
| 5 | 10 | 20 | 30 | |||
| e-Cigarette | ||||||
| V2 Menthol, range | 50.1-119.0 | 1298-3084 | 649-1542 | 325-771 | NA | 86-1608 |
| V2 Peppermint, range | 78.3-82.7 | 1868-1973 | 934-987 | 467-493 | NA | 136-1118 |
| Premium Menthol | 115.0 | 1344 | 672 | 336 | NA | 198-1554 |
| South Beach Smoke Menthol | 28.2 | 5479 | 2739 | 1370 | NA | 48-282 |
| South Beach Smoke Peppermint | 25.7 | 6012 | 3006 | 1503 | NA | 44-348 |
| Smokeless Tobacco | ||||||
| Skoal Xtra Mint snuff | 48.8 | NA | 1646 | 823 | 549 | 168-1319 (Light users)/126-990 (heavy users)d |
Abbreviation: MOE, margin of exposure.
V2 products were manufactured by VMR Products LLC; Premium products are manufactured by PremiumEStore LLC; South Beach Smoke products are manufactured by southbeachsmoke.com; and Skoal products are produced by the US Smokeless Tobacco Company.
The no observed adverse effect level for pulegone is 13.39 mg/kg of body weight/d.1,2 User body weight was assumed to be 60 kg; e-Liquid specific density equals 1.04 g/cm3.
Menthol cigarettes were estimated to contain 0.037 to 0.290 μg/g.5 Each cigarette was considered to have 1 g of tobacco; 1 pack equals 20 cigarettes.
Based on daily use, a light user is considered to consume 10 g of smokeless tobacco; a moderate user to consume 20 g of smokeless tobacco; and a heavy user to consume 30 g of smokeless tobacco.