Table 2.
List of systemic antibiotics approved by the FDA and EMA since 1999.
| Antibacterial | Year Approved | Novel Mechanism? | Spectra | |
|---|---|---|---|---|
| FDA | EMA | |||
| Quinupristin/dalfopristin | 1999 | 2000 | No | GPB |
| Moxifloxacin | 1999 | 2001 | No | GPB-GNB |
| Gatifloxacin * | 1999 | / | No | GPB-GNB |
| Linezolid | 2000 | 2001 | Yes | GPB |
| Cefditoren pivoxil | 2001 | / | No | GPB-GNB |
| Ertapenem | 2001 | 2002 | No | GNB-GPB |
| Gemifloxacin * | 2003 | / | No | GPB-GNB |
| Daptomycin | 2003 | 2006 | Yes | GPB |
| Telithromycin * | 2004 | 2001 | No | GPB |
| Tigecycline | 2005 | 2006 | Yes | GPB-GNB |
| Doripenem * | 2007 | 2008 | No | GNB-GPB |
| Telavancin | 2009 | 2011 | Yes | GPB |
| Ceftarolin fosamil | 2010 | 2012 | No | GPB-GNB |
| Ceftolozane-tazobactam | 2014 | 2015 | No | GNB-GPB |
| Tedizolid | 2014 | 2015 | No | GPB |
| Oritavancin | 2014 | 2015 | No | GPB |
| Dalbavancin | 2014 | 2015 | No | GPB |
| Ceftazidime-avibactam | 2015 | 2016 | No | GNB |
| Meropenem-vaborbactam | 2017 | 2018 | No | GPB-GNB |
| Delafloxacin | 2017 | / | No | GPB-GNB |
| Omadacycline | 2018 | / | No | GPB-GNB |