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. 2019 Sep 18;38:409. doi: 10.1186/s13046-019-1401-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — TRIP13 altered activation of PI3K/AKT/mTOR pathway to induce cell EMT. a Gene set enrichment analysis of TCGA LIHC dataset showed enrichment of PI3K/AKT/mTOR pathway and Wnt/β-catenin pathway gene panels in the TRIP13 high expression group. b Reprehensive genes of PI3K/AKT/mTOR pathway and Wnt/β-catenin pathway were detected in TRIP13 knockdown or overexpression cells. c-d Cells were treated with XAV939 or LY294002 and cell migration and invasion were measured. e Cells were treated with XAV939 or LY294002 and the levels of EMT markers were analyzed. *P < 0.05, **P < 0.01, ***P < 0.001