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. 2019 Sep 17;17:99. doi: 10.1186/s12951-019-0532-9

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© The Author(s) 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Scheme 1 — a Schematic illustration of the preparation of PC₁₀A/DOX/HAuNS nanoparticles and PC₁₀A/DOX/HAuNS hydrogel through self-assemble layer-by-layer and “dissolving” the PC₁₀A/DOX/HAuNS nanoparticles in the PC₁₀A hydrogel, respectively; b PC₁₀A/DOX/HAuNS hydrogel with sequential drug release were utilized for sustained chemotherapy and photothermal therapy in vivo