TABLE 4.

Baseline Characteristics and KOOS at Baseline and at 2 Years of Patients With Failure at 2-Year Follow-up^a

			K-L Score	Defect Size, cm2	KOOS
Surgery	Age, y	Localization			Baseline	2 y	Comments
Clinical failure
ACI-C	31	MFC	0	1.2	44.0	35.7	Diagnosed with fibromyalgia and possible ankylosing spondylitis postsurgery. Receives disability benefits.
ACI-C	33	MFC	0	3.1	68.5	47.6	Got pregnant shortly after primary surgery.
ACI-C	51	MFC and trochlea	3	4.2 and 0.8	82.7	52.4	MRI 1 y after surgery showed major degenerative changes.
AMIC	44	Trochlea and MFC	2	7.5 and 4.8	67.3	60.7b	Rearthroscopy 17 mo after surgery. Minimal regeneration cartilage and osteophyte formation in the middle of the trochlear defect. Debrided with bone cutter. Good filling of medial condyle defect.
AMIC	35	MFC	2	3.8	97.0	88.7	PCL insufficient when tested by arthroscopy at primary surgery. Not addressed. Satisfied at 1 y, but result had deteriorated at 2 y.
AMIC	38	MFC	0	2.0	70.8	68.5	Rearthroscopy within 1 y. Good filling of the defect. At 2 y, under evaluation for fibromyalgia.
Hard failure
AMIC	55	MFC	2	6.0	26.2	26.2b	Not satisfied at last follow-up after knee replacement.
AMIC	39	Trochlea	2	5.0	33.9	67.3b	Lacking information after the knee replacement.

^aACI-C, collagen-covered autologous chondrocyte implantation; AMIC, autologous matrix-induced chondrogenesis; K-L, Kellgren Lawrence; KOOS, Knee injury and Osteoarthritis Outcome Score; MFC, medial femoral condyle; MRI, magnetic resonance imaging; PCL, posterior cruciate ligament.

^bOne-year data carried forward.