Table 1.
Criteria for diagnoses in individuals with a CAG‐repeat expansion in Huntingtin
| Diagnosis | Motor | Cognitive | Potential Treatment |
|---|---|---|---|
| (1) Presymptomatic HD | Dx conf 0–2 | Normal | (1) Disease modifying |
| (2) Prodromal HD (either A or B) |
A) Dx conf 2 B) Dx conf 3 |
(A) + Minor or major neurocognitive changes (B) With normal (unchanged) cognition |
(2A or B) Symptomatic or disease modifying |
| (3) Manifest HD (either A or B) |
A) Dx conf 3 B) Dx conf 4 |
(A) + Minor or major neurocognitive changes (B) With normal (unchanged) cognition |
(3A or B) Symptomatic or disease modifying |
Potential treatments apply to each of the 3 diagnoses regardless of the criteria for meeting the diagnosis. It is expected that the ability to define signs and symptoms would be enhanced by longitudinal follow‐up and assessments.
Dx conf, Diagnostic Confidence; HD, Huntington's disease.