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. Author manuscript; available in PMC: 2019 Sep 18.
Published in final edited form as: Basic Res Cardiol. 2016 Mar 18;111(3):26. doi: 10.1007/s00395-016-0546-5

Fig. 1.

Fig. 1

Proposed common mechanism highlighting the role of these novel signaling factors in pro-inflammatory pathways within the endothelial cell. Endothelial dysfunction mobilizes pro-inflammatory mitochondrial elements and contributes to vascular disease pathogenesis. OMM outer mitochondrial membrane, IMM inner mitochondrial membrane, mtDNA mitochondrial DNA, CF6 coupling factor 6, CL cardiolipin, PHB1 prohibitin-1, mtDAMP mitochondrial damage-associated pattern