Table 2.
Demographic characteristics and associations with the Area under the curve (AUC) of the NF-κB-regulated luciferase activity.
| Variable | Coefficient | 95% Confidence intervals | p-value |
|---|---|---|---|
| Center | |||
| Aachen vs. liverpool | −0.78 | (−6.16; 4.59) | 0.771 |
| Diagnosis | |||
| CD vs. Con | −4.37 | (−11.17; 2.43) | 0.202 |
| UC vs. Con | −6.77 | (−14.13; 0.58) | 0.070 |
| Sex (male vs. female) | 0.93 | (−3.54; 5.40) | 0.678 |
| Age (in years) | 0.05 | (−0.13; 0.22) | 0.585 |
| Smoking | |||
| Current vs. never | 7.68 | (1.53; 13.83) | 0.015 |
| Previous vs. never | 0.43 | (−5.74; 6.59) | 0.890 |
| Behavior CD (B2/B3 vs. B1) | 3.84 | (−4.24; 11.93) | 0.344 |
| Immunomodulators (yes vs. no) | 0.10 | (−6.90; 7.10) | 0.978 |
| Biologics (yes vs. no) | −0.13 | (−7.43; 7.18) | 0.972 |
Linear regression was performed using 60 patients with complete metadata; Crohn's disease (CD), ulcerative colitis (UC), and healthy control donors (Con). Each coefficient was tested with t-test. For the categorical variable diagnosis, healthy controls were taken as reference. For the categorical variable smoking, never smoking was taken as a reference. For the categorical variable behavior CD, the categories B2 and B3 were grouped together, and tested against the reference B1.