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. 2019 Sep 11;10:963. doi: 10.3389/fneur.2019.00963

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Copyright © 2019 Tarczyluk-Wells, Salzlechner, Najafi, Lim, Smith, Platt, Williams and Cooper.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A 3-month treatment with Ibuprofen induces moderate improvement of motor skills in 6–9-month old Cln3^−/− mice. An accelerating rotarod (from 0 to 24 rpm in 240 s) was used to measure the motor skills of 6–9-month-old Cln3^−/− and wild type (WT) (n = 12) mice. Mice were given either powdered diet with Ibuprofen, Ibuprofen and Lamotrigine, or powdered diet with no drugs (Untreated) (n = 6–7) for 3 months. Data bars represent mean ± S.E.M. of the time (s) mice were able to stay on the rotating rod at 6–9 months of age (0–3 months of treatment). Repeated measures two-way ANOVA was applied with Bonferroni's post-test (^*p < 0.05 and ^***p < 0.001).