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Discrimination of 5-year, all-cause mortality, for VACS Index 1.0 (left) and VACS Index 2.0 (right), in combined VACS and ART-CC data subgroups. Low-Risk = age <50 years, CD4 count ≥ 200 cells/μl, and HIV-RNA ≤ 500 copies/mL. High-Risk = all others.