Appendix Table 1.

VACS Index 2.0 Cox proportional hazards model, for 5-year, all-cause mortality, estimated in Veterans Aging Cohort Study, varying length of last value carried forward (LVCF).

N deaths	Main analysis LVCF 180 days 28390 7293					Sensitivity LVCF 1 year 28830 7479

Parameter	PE	SE	χ²	p	HR (95% CI)	PE	SE	χ²	p	HR (95% CI)
Age (years), censored at 30-75, centered at (age-50)
X	0.056	0.012	22	<.0001	1.06 (1.03-1.08)	0.058	0.012	24	<.0001	1.06 (1.04-1.09)
X²	−0.004	0.004	2	0.22	1.00 (0.99-1.00)	−0.006	0.004	3	0.11	0.99 (0.99-1.00)
X³	0.005	0.001	29	<.0001	1.01 (1.00-1.01)	0.005	0.001	30	<.0001	1.01 (1.00-1.01)
CD4 cell count (cells/ml), censored at 0-1000, as ln (1000-CD4)
X	−0.056	0.025	5	0.03	0.95 (0.90-0.99)	−0.048	0.025	4	0.05	0.95 (0.91-1.00)
X²	−0.153	0.023	46	<.0001	0.86 (0.82-0.90)	−0.149	0.023	43	<.0001	0.86 (0.82-0.90)
X³	0.024	0.002	94	<.0001	1.02 (1.02-1.03)	0.023	0.002	86	<.0001	1.02 (1.02-1.03)
HIV-1 RNA (log copies/ml), censored at 1.3- 5.0, centered at (logVL - 2)
X	0.513	0.033	247	<.0001	1.67 (1.57-1.78)	0.518	0.032	257	<.0001	1.68 (1.58-1.79)
X²	−0.422	0.041	109	<.0001	0.66 (0.61-0.71)	−0.412	0.040	106	<.0001	0.66 (0.61-0.72)
X³	0.098	0.011	77	<.0001	1.10 (1.08-1.13)	0.095	0.011	73	<.0001	1.10 (1.08-1.12)
Hemoglobin (g/dl), censored at 9-16, centered at (14 - hemoglobin)
X	−0.134	0.011	141	<.0001	0.88 (0.86-0.89)	−0.132	0.011	142	<.0001	0.88 (0.86-0.90)
X²	0.026	0.006	16	<.0001	1.03 (1.01-1.04)	0.026	0.006	17	<.0001	1.03 (1.01-1.04)
X³	0.005	0.001	10	0.002	1.01 (1.00-1.01)	0.004	0.001	10	0.002	1.00 (1.00-1.01)
FIB-4, censored at .5-7.5
X	0.220	0.028	62	<.0001	1.25 (1.18-1.32)	0.213	0.028	59	<.0001	1.24 (1.17-1.31)
X²	−0.009	0.003	7	0.008	0.99 (0.99-1.00)	−0.008	0.003	7	0.0106	0.99 (0.99-1.00)
eGFR (ml/min), censored at 0-180,^*
X1	−0.031	0.028	1	0.28	0.97 (0.92-1.03)	−0.014	0.028	0	0.61	0.99 (0.93-1.04)
X2	−0.077	0.045	3	0.0917	0.93 (0.85-1.01)	−0.107	0.045	6	0.0174	0.90 (0.82-0.98)
X3	0.106	0.027	16	<.0001	1.11 (1.06-1.17)	0.131	0.026	25	<.0001	1.14 (1.08-1.20)
X4	0.133	0.034	15	0.0001	1.14 (1.07-1.22)	0.093	0.033	8	0.0054	1.10 (1.03-1.17)
Hepatitis C co-infection
Yes	0.342	0.028	147	<.0001	1.41 (1.33-1.49)	0.350	0.028	160	<.0001	1.42 (1.35-1.50)
Albumin (g/dl), censored at 2-5, centered at (albumin - 4)
X	−0.443	0.034	165	<.0001	0.64 (0.60-0.69)	−0.467	0.034	189	<.0001	0.63 (0.59-0.67)
X²	0.104	0.051	4	0.04	1.11 (1.00-1.23)	0.141	0.050	8	0.01	1.15 (1.04-1.27)
X³	0.028	0.027	1	0.30	1.03 (0.98-1.08)	0.055	0.026	4	0.04	1.06 (1.00-1.11)
White blood count (k/ml), censored at 2.5-11, centered at (WBC - 5.5)
X	0.126	0.011	130	<.0001	1.13 (1.11-1.16)	0.125	0.011	132	<.0001	1.13 (1.11-1.16)
X²	0.020	0.004	30	<.0001	1.02 (1.01-1.03)	0.021	0.004	35	<.0001	1.02 (1.01-1.03)
X³	−0.004	0.001	23	<.0001	1.00 (0.99-1.00)	−0.005	0.001	27	<.0001	1.00 (0.99-1.00)
Body mass index, kg/m2, censored at 15-35, centered at (BMI - 25)
X	−0.055	0.003	388	<.0001	0.95 (0.94-0.95)	−0.055	0.003	407	<.0001	0.95 (0.94-0.95)
X²	0.004	0.000	62	<.0001	1.00 (1.00-1.01)	0.004	0.000	62	<.0001	1.00 (1.00-1.00)

X1 = eGFR/10, X2 = (eGFR-35)/10, X3 = (eGFR-65)/10, X4 = (eGFR-115)/10.