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. Author manuscript; available in PMC: 2020 May 8.
Published in final edited form as: Cell Host Microbe. 2019 Apr 23;25(5):656–667.e8. doi: 10.1016/j.chom.2019.03.007

Figure 3 |. Mobile elements are transferred within the microbiome of individual people.

Figure 3 |

(A-B) The phylogeny of isolates from L04 illustrates the gain of MED04–1 over time. Shading reflects the average relative coverage of the MED (compared to the mean genomewide). (B) Average relative coverage across the length of MED04–1 for different samples. Colors are as indicated in (A). (C-D) Combining isolate whole genomes and metagenomes reveals an inter-species mobile element transfer event. (C) Metagenomic libraries from both time points of L01 show high relative coverage of a putative integrative conjugative element (ICE), while only isolates from the later timepoint have coverage of this ICE. Isolates from one sample show slightly higher relative coverage as these genomic were prepared differently (Methods). (D) A rooted parsimonious phylogeny of the putative ICE across 4 species. Isolates with identical ICE sequences from a same phylogenetic group were merged into a single node (see also Figures S1B–S1C).