Table 1.
Review of publications finally included in the full-text analysis
| Publication | n | n studied group (girls) | n g. control (girls) | Diagnosis | Participants’ age M (SD) | Conclusion | Materials and methods | Publication’s evaluationd |
|---|---|---|---|---|---|---|---|---|
| Taurines et al, 201412 | 36 | 19 | 17 | DSM; ADI-R; ADOS | 10.7 (3.8) years | OXT in the ASD group (p=0.132)b | Plasma RIA |
8 |
| Modahl et al, 199831 | 59 | 29 | 30 | DSM | 8.08 (1.6) years | OXT in the ASD groupc | Plasma RIA |
6.5 |
| Alabdali et al, 201432 | 80 | 50 | 30 | DSM | 7.0 (2.34) years | OXT in the ASD groupc | Plasma ELISA |
6 |
| Green et al, 200133 | 59 | 28 | 31 | DSM | 8.08 (1.6) years 5.8–11.58 years |
OXT in the ASD groupc | Plasma RIA |
5.5 |
| Al-Ayadhi 200519 | 154 | 77 (6) | 77 (6) | DSM | 3.5–14 years | OXT in the ASD groupc AVP in the ASD groupc |
Plasma ELISA |
4 |
| Abdulamir et al, 201634 | 86 | 60 | 26 | DSM | 7.28 (2.89) years | OXT in the ASD groupc | Plasma ELISA |
6 |
| Althaus et al, 201615 | 61 | 31 | 30 | DSM | 22.67 (422) years 18–34 years |
OXT in the ASD group (p=0.05)b | Plasma RIA |
7.5 |
| Boso et al, 200720 | 39 | 18 (2) | 21 (3) | DSM | 27.5 (7.2) years 15–42 years |
AVP in the ASD groupa | Plasma ELISA |
5 |
| Zhang et al, 201617 | 169 | 84 (13) | 85 (14) | DSM | 3.95 (1.26) years 2–7 years |
OXT in the ASD groupc AVP in the ASD group (p=0.477)b |
Plasma ELISA |
7.5 |
| Carson et al, 201521 | 112 | 57 (9) | 55 (19) | DSM; ADI-R; ADOS | 8.58 (0.45) years | No differences between the groups (AVP; p>0.05) | Plasma ELISA |
6 |
| Miller et al, 201311 | 75 | 40 (19) | 35 (16) | DSM; ADI-R; ADOS | 8–18 years | No differences between the groups (OXT; p>0.05) No differences between the groups (AVP; p>0.05) |
Plasma ELISA |
7.5 |
| Jacobson et al, 201416 | 78 | 37 (12) | 41 (17) | DSM; ADI-R; ADOS | 4.73 (0.61) years | OXT in the ASD groupa | Plasma ELISA |
8 |
Notes: aIncreased level; bIncreased level but statistically insignificant result; cDecreased level. dAccording to the Newcastle–Ottawa Quality Assessment Scale for Case Control Studies – max 9 pkt.
Abbreviations: DSM, diagnostic and statistical manual of mental disorders IV-TR; ADI-R, autism diagnostic interview – reviewed; ADOS, autism diagnostic and observation schedule; OXT, oxytocin; ASD, autism spectrum disorde; ELISA, enzyme-linked immunorbent assay; AVP, arginine-vasopressin.