Fig. 5.

Effects of repeated saline or MA injections on core body temperature. Taar1 WT and KO mice received four intraperitoneal injections (indicated by arrows) of saline (A) or MA (B; 5 mg/kg), 2 hours apart. Body temperature was measured every 15 minutes via telemetry over 8 hours in an ambient temperature environment of 23 ± 1°C. Data represent temperature for each genotype and treatment group (mean ± S.E.M.) at specified time points, n = 11–12 mice per genotype per treatment group. Time points selected for detailed analysis were 30 minutes after each injection. *P < 0.01; **P < 0.0001 between genotypes.