TABLE 4.

MA-induced change in body temperature relative to saline-treated mice

Data represent change (ΔT) in temperature (mean ± S.E.M.) for each treatment group from saline-treated mice at the specified time point; n = 11–12 mice per genotype per treatment group. Taar1 WT saline-treated group body temperature at each timepoint (mean ± S.E.M.): 1st inj, 37.9 ± 0.1°C; 2nd inj, 37.7 ± 0.1°C; 3rd inj, 37.3 ± 0.1°C; 4th inj, 37.1 ± 0.1°C. Taar1 KO saline-treated group body temperature at each timepoint: 1st inj, 37.7 ± 0.2°C; 2nd inj, 37.6 ± 0.1°C; 3rd inj, 37.2 ± 0.1°C; 4th inj, 36.7 ± 0.1°C.

Genotype	MA Dose (mg/kg)	30 Min Post-Injection (ΔT °C ± S.E.M.)
		1st Inj	2nd Inj	3rd Inj	4th Inj
Taar1 WT	5	−2.0 ± 0.2*	−0.7 ± 0.3**	−0.1 ± 0.2	−0.3 ± 0.2
Taar1 KO	5	−0.2 ± 0.2	0.5 ± 0.1**	0.3 ± 0.2	−0.2 ± 0.2

^*P < 0.01 compared with saline-treated mice;

^**P < 0.05 compared with saline-treated mice.