Fig. 5.

Transcription factor and nuclear receptor genes identified in enhancer-promoter TAD loops within neurogenic transcriptional networks in studies from the PsychENCODE Consortium and related research. (A) Output from IPA (Krämer et al., 2013) of a highly interconnected pathway involved in neurologic development and disorders (P = 1 × 10E−130). (B) Top upstream chemical-drug regulators of the network shown in (A) as determined by IPA and KEGG (Kanehisa et al., 2016). (C) Top five human neurologic disorders significantly associated with neurogenic network. (D) Top five human nervous system biologic processes. (E) Top five molecular functions determined by Gene Ontology (The Gene Ontology Consortium, 2019). For gene names, please see Supplemental Table 2.