TABLE 3.

Observed and predicted V_ss and EOC values for both methods

Test Drug	Observed Vss	Predicted Vss		EOC
		Kp,mem Method	Kp,dPL Method	Kp,mem Method	Kp,dPL Method
	l	l	l
Betaxolol	360	307	856	0.97	0.61
Diltiazem	306	320	309	0.76	0.80
Diphenhydramine	788	260	115	0.97	0.87
Metoprolol	274	429	217	0.76	0.87
Mibefradil	187	1470	53.2	0.81	0.82
Nicardipine	62	96.4	98.5	0.79	0.78
Quinidine	227	78.3	215	0.96	0.73
Verapamil	266	258	136	0.73	0.76
Caffeine	42.8	47.0	36.7	0.87	0.93
Diazepam	89.5	22.9	30.5	0.55	0.61
Felodipine	320	74.3	43.4	0.68	0.56
Fluconazole	59.3	83.4	49.1	0.85	0.99
Midazolam	51.2	64.1	113	0.82	0.71
Phenytoin	38.8	77.0	79.1	0.78	0.77
Diclofenac	9.23	7.98	7.89	0.84	0.84
Glyburide	11.78	10.2	10.0	0.86	0.87
Ketoprofen	9.9	8.54	8.47	0.89	0.89
Nafcillin	20.4	12.2	10.1	0.86	0.81
Warfarin	7.66	8.20	8.15	0.96	0.97
			Average	0.82 ± 0.11	0.80 ± 0.12