Fig. 6.

ZLN-024 treatment blocks hyperalgesic priming in male and female mice but had no effect on acute incision-induced mechanical hypersensitivity: (A–F). Although ZLN-024 treatment starting immediately after baseline measurements had no effect on initial mechanical hypersensitivity after plantar incision surgery, drug treatment was effective in preventing plantar incision-induced hyperalgesic priming precipitated by PGE₂ injection in male (A–C) and female (D–F) mice. *P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001; n = 6 for the ZLN-024 group, n = 6 for the vehicle group.