Fig. 8.

Local MK8722 treatment attenuates hyperalgesic priming in male and female mice but had no effect on acute incision-induced mechanical hypersensitivity: Local injection of MK8722 at the time of incision and again 24 hours later (red arrows) had no effect on initial mechanical hypersensitivity after plantar incision surgery in male or female mice; however, drug treatment was effective in prevention of plantar incision-induced hyperalgesic priming precipitated by PGE₂ injection in male (A–C) and female (D–F) mice. *P < 0.05; **P < 0.01; ***P < 0.001; n = 4 for the MK8722 group, n = 4 for the vehicle group in both male and female mice.