Plasma concentrations and biliary excretion rates of DCF, OH-DCF, and DCF-AG in C57 WT and C57 Bcrp KO mice after 10-mg/kg-DCF dose. Pharmacokinetics of DCF and its metabolites in WT (○) and Bcrp KO (●) mice after a single intra-arterial dose of 10 mg/kg DCF. (A–C) Plasma concentration profiles for DCF (A), OH-DCF (B), and DCF-AG (C) at discrete time points. (D–F) Biliary excretion profiles for DCF (D), OH-DCF (E), and DCF-AG (F).