TABLE 1.

Summary of DCF pharmacokinetic parameters in plasma of WT and KO mice after a single 3- or 10-mg/kg-DCF dose

Parameters of C₀, t_1/2, and AUC_0-tlast were calculated using noncompartmental analysis. Each value represents the mean ± S.E.M. of five to seven subjects/group.

Genotype	C0	t1/2	AUC0-tlast
	µM	min	µM × min
3 mg/kg
C57 WT	57.8 ± 6.0	31.2 ± 4.0	1050 ± 50
C57 BCRP KO	46.0 ± 5.1	27.8 ± 3.6	1020 ± 80
10 mg/kg
C57 WT	132 ± 8	30.5 ± 3.1	3420 ± 290
C57 BCRP KO	201 ± 44	33.5 ± 2.5	3570 ± 340
3 mg/kg
FVB WT	51.4 ± 5.1	24.0 ± 4.1	862 ± 86
FVB Mrp3 KO	41.2 ± 3.3	37.5 ± 9.2	1110 ± 130
10 mg/kg
FVB WT	178 ± 16	37.8 ± 5.6	4220 ± 420
FVB Mrp3 KO	172 ± 13	52.9 ± 9.8	4770 ± 280

AUC_0-tlast, from time 0 to the last measurable concentration.