TABLE 2.

Summary of in vitro DCF metabolism in mouse models

Metabolic parameters were determined using S9 fraction from FVB and C57 strains of mice that were WT or KO for Mrp3. Data represent the mean ± S.E.M. from two separate studies.

Genotype	Vmax	Km	Metabolic CLint
	pmol/min/mg	µM	µl/min/mg
C57 WT	846 ± 31	69.3 ± 4.3	12.2
C57 KO	882 ± 26	82.4 ± 1.1	10.7
FVB WT	734 ± 32	44.3 ± 3.5	16.7
FVB KO	696 ± 79	43.3 ± 9.0	16.4

CL_int, intrinsic uptake clearance.