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. 2019 Oct;96(4):505–514. doi: 10.1124/mol.119.117358

Fig. 7.

Fig. 7.

After chronic treatment with morphine, the TSST-4E mutant MOR separates induction of changes in acute desensitization (present) from the decrease in the sensitivity to morphine (blocked). (A) Snake plot shows the sites with glutamate substitutions (blue, T354, S355, S356. T357). (B) An example of acute ME-induced desensitization and recovery from desensitization in a slice from an MTA. (C) Summary of experiments showing recovery from desensitization in slices from untreated (black) and MTAs (red). (D) Summarized results showing the decline from the peak current induced by ME (30 µM, 10 minutes) and the amplitude of the ME (0.3 µM) current relative to the peak current induced by ME (30 µM) in slices from untreated and MTAs. (E) Dot plot of the relative current induced by morphine (1 µM) relative to the peak current induced by ME (30 µM, I-morphine/I-ME) showing that there was no change in the relative morphine current between slices from untreated and MTAs (untreated 0.48 ± 0.18, MTA 0.47 ± 0.16, 95% confidence level). *P < 0.05.