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. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Am J Hematol. 2018 Sep 26;93(10):1245–1253. doi: 10.1002/ajh.25234

Figure 1. Heterogeneity and divergent outcomes among IPSS-R intermediate-risk patients.

Figure 1.

A: Variability and distribution of IPSS-R int-risk MDS patients. Top panel shows distribution of survival times vs. age. Bottom panel shows histogram of overall survival (bin width=6 months). Black curve shows non-linear fit of histogram of non-censored survival times using two Gaussian curves. B: Distribution of patients by sequentially stratification, based on the sum of three classification parameters: age (0 or 2 points), PB blasts (0 or 1 point), and RBC transfusion history (0 or 1 point). Each numerical score is subdivided to indicate how patients achieved specified scores. C: Overall survival among patients with IPSS-R intermediate-risk MDS according to two prognostic groups sequentially stratified as described, according to age, PB blasts, and transfusion history. D: Transfused units of red blood cells and platelets per patient year among int-favorable and int-adverse patients who required transfusions after diagnosis of MDS (p=<0.0001 for both red blood cells and platelets).