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. Author manuscript; available in PMC: 2019 Sep 18.
Published in final edited form as: Ann Integr Mol Med. 2019;1(1):1002.

Figure 8: RNA-dependent mRNA amplification process may activate a dormant protein-encoding information and generate polypeptides non-contiguously encoded in the genome.

Figure 8:

Boxed line: sense strand RNA. Single line: antisense strand RNA. “AUG” (in blue): functional translation initiation codon (could be other than “AUG”). 5’-CAU-3’ (in blue) on the sense RNA: complement of 5’-AUG-3’ on the antisense RNA. Red arrow: position of cleavage of the chimeric intermediate. A: genome-originated “dormant” mRNA containing protein-encoding information but lacking in-frame translation initiation codon. B: antisense complement of conventional mRNA. Note that 3’-GUA-5’(in blue) is the 5’-AUG-3’. C: folding of the antisense strand into self-priming configuration. D: extension of self-primed antisense strand into sense-oriented sequence followed by strand separation and cleavage of the chimeric intermediate. E: end products of RNA-dependent mRNA amplification. Note that translation of the chimeric RNA end product starts from the antisense RNA-originated initiation codon (“AUG”, in ‘‘blue) and produces a chimeric polypeptide non-contiguously encoded in the genome.