Figure 2.

B and T cells in myelomagenesis and association with immunoparesis (A) B cells over the course of myelomagenesis with SMM cohort delineated based on Spanish PETHEMA risk stratification. Immunoparesis is associated with decreased B cells in SMM patients. (B) T cells over the course of myelomagenesis, with SMM risk stratified as above. Similar trends for B and T cells were observed when SMM cohort was risk stratified using Mayo Clinic model or using immunoparesis (data not shown). Box plots in this figure use N = 6 instead of N = 11 for MM patients. Risk stratification of SMM patients and box plots as described in Figure 1 legend. Sample sizes and statistical analyses as described in the text.