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. Author manuscript; available in PMC: 2019 Sep 18.
Published in final edited form as: Ann Pancreat Cancer. 2019 Jun 20;2:12. doi: 10.21037/apc.2019.06.02

Table 4.

List of PNET mouse models

Genetic modification Phenotype Incidence Tumor latency References
RIP-Tag Insulinoma 100% 12 to 16 weeks (46)
RIP-Tag; RIP-tva Insulinoma 100% 12 to 16 weeks (47,48)
Men1 knockout and conditional knockout PNETs and, less frequently, pituitary adenomas, and parathyroid adenomas 5 to 13 months (49)
pINS-c-MycERTAM complete ablation of β cells 100% 6~10 days (50)
pINS-c-MycERTAM; RIP7-Bcl-xL Insulinoma 100% within 2 weeks (50)
LSL-MYCN; hGFAP-Cre PNETs and, less frequently, pituitary gland malignancies 59% 6 to 11 months (51)
Ren-Cre; p53loxP/loxP; RbloxP/loxP glucagonomas with metastases 100% ~4 months (52)
RIP-rtTA, tet-o-PyMT-IRES-Luciferase p-cell hyperplasia when on doxycycline 100% No tumors (53)