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. Author manuscript; available in PMC: 2020 Mar 1.
Published in final edited form as: Exp Physiol. 2019 Jan 15;104(3):385–397. doi: 10.1113/EP087429

Table 1.

Animal Characteristics

WT
KO
Control IL-6 Control IL-6
n 14 15 12 11
Body Weights (g)
Pre 23.3 ± 1.5 23.4 ± 1.9 24.7 ± 2.0 24.0 ± 1.7
Mid 24.0 ± 1.5 23.4 ± 1.4 24.9 ± 2.0 24.1 ± 1.3
Post 24.9 ± 2.0 24.0 ± 2.1 25.1 ± 1.3 24.3 ± 1.7
Plasma IL-6 (pg/mL)
Pre - - - -
Mid -   63 ± 52* -   98 ± 55&
Post -   75 ± 43* - 141 ± 31&
Tissues at Sacrifice
Hindlimb (mg) 207 ± 14 200 ± 14  214 ± 11@  206 ± 14@
Hindlimb/Tibia
(mg/mm)
12.2 ± 0.7 12.0 ± 0.7  12.7 ± 0.6  12.3 ± 0.8
Tibia Length (mm) 17.0 ± 0.3 16.8 ± 0.2# 16.8 ± 0.2 16.7 ± 0.2#
Epididymal Fat (mg)  362 ± 139  313 ± 96 308 ± 52 290 ± 85
Spleen (mg)  71 ± 12 122 ± 26#   93 ± 68 199 ± 92#

Values are means ± SD. Male C57BL/6 (WT) mice. Male skeletal muscle specific gp130 knockout (KO) mice. Age in weeks (wks). Body weight in grams (g). Plasma interleukin-6 (IL-6) in picograms/milliliters (pg/mL). All vector controls and pre-IL-6 levels fell below the detection limit and therefore weren’t reported. Combined weight of the soleus, plantaris, gastrocnemius, and tibialis anterior (hindlimb) in milligrams (mg). Tibia length in millimeters (mm). Epididymal fat pad weight in milligrams. Spleen weight in milligrams. Significance set at p<0.05 (Two-Way ANOVA).

#

Significant main effect of IL-6.

@

Significant main effect of KO. & Significantly different from all groups.

*

WT-IL-6 significant interaction from all groups.

&

KO-IL-6 significant interaction from all groups.

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