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. Author manuscript; available in PMC: 2020 Sep 5.
Published in final edited form as: Cell. 2019 Sep 5;178(6):1313–1328.e13. doi: 10.1016/j.cell.2019.08.010

Figure 6. Perturbation of secondary bile acids is associated with elevated NLRP3 inflammasome signaling in antibiotics-treated subjects.

Figure 6.

(A) Circos plot showing the log2 fold change in secondary bile acids, antibiotics-induced BTMs (Figure 4A), and inflammasome signaling genes on days 0-7 relative to screening (day −21) in control and antibiotics-treated subjects. Lines indicate significant correlations (p<0.01, Pearson correlation across all time points).

(B) Scatterplot of FOSB expression versus fold change of LCA in the plasma (all time points). Each dot represents one subject.

(C-D) Fold change of genes in M35.0 in (C) antibiotics-treated and (D) control subjects. Each “edge” (gray line) represents a coexpression relationship; colors represent the day 1 versus screening (day −21) log2 fold change (positive – yellow, negative – blue).

(E) Fold change of LCA in the plasma among antibiotics-treated (red) and control (blue) subjects. Each thin line represents a single subject, thick lines represent geometric means.

See also Figure S4 for comparison of LCA fold changes in phases 1 and 2.